Preparation of substituted pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines via a Pictet-Spengler cyclization

J Org Chem. 2005 Nov 11;70(23):9629-31. doi: 10.1021/jo051419g.

Abstract

[Reaction: see text]. A synthesis of the title compounds, which have found use as inhibitors of certain receptor tyrosine kinases, was achieved using a Pictet-Spengler cyclization as a key step.

MeSH terms

  • Azepines / chemical synthesis*
  • Azepines / chemistry*
  • Catalysis
  • Cyclization
  • Molecular Structure

Substances

  • Azepines