Abstract
The administration of single-dose nevirapine to women in labor and their infants can prevent HIV-1 mother-to-child transmission. We examined nevirapine resistance in infants who were HIV-1 infected despite single-dose nevirapine prophylaxis, including 18 Ugandan infants (HIVNET 012 trial, nine subtype A and nine subtype D) and 23 Malawian infants (NVAZ trial, all subtype C). Nevirapine resistance was more frequent in infants with subtype C than with subtypes A and D (87 versus 50%, P = 0.016).
Publication types
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Clinical Trial
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-HIV Agents / administration & dosage*
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Drug Resistance, Viral
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Female
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HIV Infections / prevention & control*
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HIV Infections / transmission
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HIV-1*
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Humans
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Infant
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Infant, Newborn
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Infectious Disease Transmission, Vertical / prevention & control
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Malawi
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Nevirapine / administration & dosage*
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Pregnancy
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Pregnancy Complications, Infectious / prevention & control*
Substances
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Anti-HIV Agents
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Nevirapine