Abstract
Laz, a lipid-modified azurin of the human pathogens Neisseria gonorrhoeae and Neisseria meningitidis, is involved in defense against oxidative stress and copper toxicity; laz mutant strains are hypersensitive to hydrogen peroxide and copper. The N. gonorrhoeae laz mutant also has decreased survival in an ex vivo primary human ectocervical epithelial assay.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Azurin / genetics
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Azurin / metabolism*
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Cells, Cultured
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Cervix Uteri / microbiology*
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Copper / pharmacology
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Drug Resistance, Bacterial*
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Epithelial Cells / microbiology
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Female
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Humans
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Hydrogen Peroxide / pharmacology
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Mutation
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Neisseria gonorrhoeae / drug effects*
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Neisseria gonorrhoeae / genetics
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Neisseria gonorrhoeae / pathogenicity
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Neisseria meningitidis / drug effects*
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Neisseria meningitidis / genetics
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Neisseria meningitidis / pathogenicity
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Oxidative Stress
Substances
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Azurin
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Copper
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Hydrogen Peroxide