Abstract
Pedigrees from 269 patients with frontotemporal lobar degeneration (FTLD), including frontotemporal dementia (FTD), FTD with ALS (FTD/ALS), progressive nonfluent aphasia, semantic dementia (SD), corticobasal degeneration, and progressive supranuclear palsy were analyzed to determine the degree of heritability of these disorders. FTD/ALS was the most and SD the least heritable subtype. FTLD syndromes appear to have different etiologies and recurrence risks.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Amyotrophic Lateral Sclerosis / complications
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Amyotrophic Lateral Sclerosis / genetics
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Aphasia, Primary Progressive / genetics
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Chromosome Disorders / genetics
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Cohort Studies
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Dementia / genetics*
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Family Health
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Female
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Genetic Predisposition to Disease / genetics*
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Genetic Testing
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Humans
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Inheritance Patterns / genetics*
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Male
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Middle Aged
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Mutation / genetics
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Pedigree
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Retrospective Studies
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Supranuclear Palsy, Progressive / genetics
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Tauopathies / genetics*
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tau Proteins / genetics