Chromosomal localization of human O6-methylguanine-DNA methyltransferase (MGMT) gene by in situ hybridization

Mutagenesis. 1992 Jan;7(1):83-5. doi: 10.1093/mutage/7.1.83.

Abstract

Recombinant lambda phage DNA containing segments of human O6-methylguanine-DNA transferase gene was employed to localize this gene among the human chromosomes using non-radioactive in situ hybridization technique. This gene was found to be present at the telomeric end, 26q, of the long arm of the chromosome 10.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping / methods*
  • Chromosomes, Human, Pair 10
  • DNA / genetics
  • Humans
  • Methyltransferases / genetics*
  • Nucleic Acid Hybridization*
  • O(6)-Methylguanine-DNA Methyltransferase

Substances

  • DNA
  • Methyltransferases
  • O(6)-Methylguanine-DNA Methyltransferase