Objective: To explore the possibility and the optimal extraction technology of astragaloside IV by SFE-CO2.
Methods: According the content of astragaloside IV, the optimum extraction technology parameters such as extraction temperature, pressure, extraction time, velocity of fluid and co-solvent were investigated and the result was compared with that of water extraction.
Results: The optimum technical parameters were as follows: Extracting pressure 40 Mpa, temperature 45 degrees C, extracting time 2h, co-solvent was 95% ethanol and its dosage was 4ml/g, the ratio of CO2 fluid was 10 kg/kg x h.
Conclusion: Extraction technology of astragaloside IV by SFE-CO2 is reliable, stable.