Abstract
Schistosoma japonicum glutathione S-transferase (SjGST) is a common fusion tag in recombinant protein production, and its 3-dimensional structure has been studied in the context of drug design. We have determined the crystal structure of non-fused SjGST complexed with glutathione, and compare it to complexes between glutathione and SjGST fusion proteins.
MeSH terms
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Animals
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Crystallography, X-Ray
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Glutathione / chemistry*
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Glutathione / metabolism*
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Glutathione Transferase / chemistry*
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Glutathione Transferase / genetics
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Glutathione Transferase / metabolism*
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Models, Molecular
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Protein Structure, Quaternary
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Protein Structure, Tertiary
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Recombinant Proteins / chemistry
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Recombinant Proteins / genetics
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Recombinant Proteins / metabolism
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Schistosoma japonicum / enzymology*
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Schistosoma japonicum / genetics
Substances
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Recombinant Proteins
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Glutathione Transferase
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Glutathione