Abstract
In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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Gene Expression Regulation, Bacterial / immunology*
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Inbred DBA
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Molecular Sequence Data
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / pathogenicity
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Protein Processing, Post-Translational / immunology*
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Sigma Factor / biosynthesis
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Sigma Factor / genetics*
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Sigma Factor / physiology
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Tuberculosis, Pulmonary / microbiology
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Tuberculosis, Pulmonary / mortality
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Virulence Factors / biosynthesis
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Virulence Factors / genetics*
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Virulence Factors / physiology
Substances
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Sigma Factor
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Virulence Factors