Abstract
A cDNA clone encoding a human endothelin receptor was isolated from a placenta cDNA library. The deduced amino acid sequence of the clone is 94% identical to the bovine endothelin ETA receptor and represents the human homologue. The human endothelin ETA receptor gene was localized to chromosome 4 by analysis of its segregation pattern in rodent-human hybrids.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Cattle
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Chromosome Mapping
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Chromosomes, Human, Pair 4*
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Cloning, Molecular / methods
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Endothelins / metabolism
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Humans
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Hybrid Cells / physiology
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Molecular Sequence Data
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Plasmids
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Polymerase Chain Reaction
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Rats
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Receptors, Cell Surface / genetics*
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Receptors, Endothelin
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Restriction Mapping
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Sequence Homology, Nucleic Acid
Substances
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Endothelins
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Receptors, Cell Surface
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Receptors, Endothelin