Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord

Glia. 2006 Jul;54(1):35-46. doi: 10.1002/glia.20354.

Abstract

Oligodendrocytes and their precursors serve critical roles in the maintenance of neurological function. Although activity of the transcription factors (TFs) Olig1, Olig2, Sox10, and Nkx2.2 is required during early oligodendrocyte development, their later expression in adult central nervous system is rather poorly characterized. Here we have analyzed co-expression patterns of these transcriptional proteins in the mouse cervical spinal cord. Our findings indicate that TF co-expression patterns describe heterogeneity in adult oligodendroglial populations (1) in distinct sub-regions of grey and white matter and (2) with respect to level of maturation from proliferating precursors to myelinating oligodendrocytes. Our findings suggest that TF co-expression patterns identify and might regulate distinct functional classes of grey and white matter oligodendroglia.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens / genetics
  • Antigens / metabolism
  • Autophagy-Related Proteins
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Basic Helix-Loop-Helix Transcription Factors / metabolism
  • Cell Count
  • Cell Differentiation / genetics*
  • Cell Lineage / genetics
  • Cell Proliferation
  • Gene Expression Regulation, Developmental / genetics*
  • High Mobility Group Proteins / genetics
  • High Mobility Group Proteins / metabolism
  • Homeobox Protein Nkx-2.2
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / metabolism
  • Immunohistochemistry
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Myelin Sheath / metabolism
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Oligodendrocyte Transcription Factor 2
  • Oligodendroglia / cytology
  • Oligodendroglia / metabolism*
  • Proteoglycans / genetics
  • Proteoglycans / metabolism
  • SOXE Transcription Factors
  • Spinal Cord / cytology
  • Spinal Cord / metabolism*
  • Stem Cells / cytology
  • Stem Cells / metabolism*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Zebrafish Proteins

Substances

  • Antigens
  • Autophagy-Related Proteins
  • Basic Helix-Loop-Helix Transcription Factors
  • High Mobility Group Proteins
  • Homeobox Protein Nkx-2.2
  • Homeodomain Proteins
  • Intracellular Signaling Peptides and Proteins
  • Nerve Tissue Proteins
  • Nkx2-2 protein, mouse
  • Olig1 protein, mouse
  • Olig2 protein, mouse
  • Oligodendrocyte Transcription Factor 2
  • Proteoglycans
  • Rb1cc1 protein, mouse
  • SOXE Transcription Factors
  • Sox10 protein, mouse
  • Transcription Factors
  • Zebrafish Proteins
  • chondroitin sulfate proteoglycan 4
  • nkx2.2b protein, zebrafish