If the prophet does not come to the mountain: dynamics of signaling complexes in NF-kappaB activation

Andrew Kovalenko; David Wallach

doi:10.1016/j.molcel.2006.05.002

If the prophet does not come to the mountain: dynamics of signaling complexes in NF-kappaB activation

Mol Cell. 2006 May 19;22(4):433-6. doi: 10.1016/j.molcel.2006.05.002.

Authors

Andrew Kovalenko¹, David Wallach

Affiliation

¹ Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel.

PMID: 16713572
DOI: 10.1016/j.molcel.2006.05.002

Abstract

Recruitment of the NF-kappaB-activating IKK signaling complex to the TNF receptor is shown to be driven by induced binding of NEMO, a regulatory component of this complex, to K63-linked polyubiquitin chains attached to RIP1, a receptor-associated adaptor protein (Ea et al., 2006 [in a recent issue of Molecular Cell]; Li et al., 2006; Wu et al., 2006a).

Publication types

Review

MeSH terms

Humans
I-kappa B Kinase / metabolism
Models, Biological
NF-kappa B / metabolism*
Nuclear Pore Complex Proteins / metabolism
RNA-Binding Proteins / metabolism
Signal Transduction
Ubiquitin / metabolism

Substances

AGFG1 protein, human
IKBKG protein, human
NF-kappa B
Nuclear Pore Complex Proteins
RNA-Binding Proteins
Ubiquitin
I-kappa B Kinase