Rate of force production and relaxation is impaired in patients with focal hand dystonia

Parkinsonism Relat Disord. 2006 Sep;12(6):363-71. doi: 10.1016/j.parkreldis.2006.01.008. Epub 2006 May 30.

Abstract

One factor, which may contribute to slowed movement in dystonia, is impairment in controlling the voluntary rate of motor output. This study examined the ability of patients with focal hand dystonia to rapidly turn force on and off at the wrist and elbow joints. Dystonic patients were slower than controls in rapidly turning on force from rest at both joints, passively relaxing force and rapidly reversing force output from a steady-state flexion contraction. Adding a preload did not improve the ability of dystonic subjects to rapidly turn on force. These results support the idea that dystonia is a disorder of impaired motor cortical activation, possibly due to basal ganglia dysfunction.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Biomechanical Phenomena
  • Data Interpretation, Statistical
  • Dystonic Disorders / diagnosis
  • Dystonic Disorders / physiopathology*
  • Elbow Joint / physiopathology
  • Female
  • Hand / innervation
  • Hand / physiopathology
  • Handwriting
  • Humans
  • Isometric Contraction
  • Male
  • Middle Aged
  • Motor Cortex / physiopathology
  • Muscle Contraction / physiology
  • Muscle Relaxation / physiology
  • Muscle, Skeletal / physiopathology*
  • Wrist Joint / physiopathology