Zernike polynomials have been widely used to describe the aberrations in wavefront sensing of the eye. The Zernike coefficients are often computed under different aperture sizes. For the sake of comparison, the same aperture diameter is required. Since no standard aperture size is available for reporting the results, it is important to develop a technique for converting the Zernike coefficients obtained from one aperture size to another size. By investigating the properties of Zernike polynomials, we propose a general method for establishing the relationship between two sets of Zernike coefficients computed with different aperture sizes.