Abstract
Five new stemoninine-type alkaloids, bisdehydrostemoninine (1), isobisdehydrostemoninine (2), bisdehydroneostemoninine (3), and bisdehydrostemoninines A (4) and B (5), were isolated from the crude-alkaloid extract of the roots of Stemona tuberosa. Their structures were elucidated on the basis of one- and two-dimensional NMR and other spectroscopic studies. The relative configuration of 4 was determined by X-ray diffraction. Alkaloid 1 displayed significant antitussive activity in the citric acid-induced guinea pig cough model.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Antitussive Agents / chemistry
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Antitussive Agents / isolation & purification*
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Antitussive Agents / pharmacology
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Crystallography, X-Ray
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Guinea Pigs
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Models, Animal
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Pyrrolidines / chemistry
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Pyrrolidines / isolation & purification*
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Pyrrolidines / pharmacology
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Stemonaceae / chemistry*
Substances
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Alkaloids
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Antitussive Agents
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Drugs, Chinese Herbal
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Lactones
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Pyrrolidines
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stemonine