Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides

MeSH terms

• Animals
• Antipsychotic Agents / chemical synthesis
• Antipsychotic Agents / chemistry*
• Antipsychotic Agents / pharmacology*
• Benzamides / chemistry*
• Drug Design*
• Glycine Plasma Membrane Transport Proteins / antagonists & inhibitors*
• Mice
• Mice, Inbred DBA
• Rats
• Schizophrenia / drug therapy
• Structure-Activity Relationship
• Sulfonamides / chemistry*