Abstract
Induction in vivo of antiviral cytotoxic T cell response was achieved in a MHC class I-dependent fashion by immunizing mice three times with a free unmodified 15-mer peptide derived from the nucleoprotein of lymphocytic choriomeningitis virus in IFA. The effector T cells are CD8+, restricted to the class I Ld allele of the analyzed mouse strain, and are specific both at the level of secondary restimulation in vitro and at the effector T cell level. These results suggest that cocktails of viral peptides may be used as antiviral T cell vaccines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Cells, Cultured
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Cytotoxicity, Immunologic
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Epitopes / analysis
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H-2 Antigens / immunology
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Lymphocytic Choriomeningitis / immunology*
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Lymphocytic Choriomeningitis / prevention & control
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Lymphocytic choriomeningitis virus / immunology*
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Mice
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Mice, Inbred BALB C
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Molecular Sequence Data
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Nucleoproteins / immunology
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Peptides / chemical synthesis
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T-Lymphocytes, Cytotoxic / immunology*
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Vaccines*
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Vaccines, Synthetic*
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Viral Vaccines*
Substances
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Epitopes
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H-2 Antigens
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Nucleoproteins
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Peptides
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Vaccines
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Vaccines, Synthetic
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Viral Vaccines