Abstract
Weak mutators are common among clinical isolates of Escherichia coli. We show that the relative mutation rate and the "evolvability of fluoroquinolone resistance" are related by a power law slope of 1.2 over 3 orders of magnitude. Thus, even weak mutators can drive the evolution of fluoroquinolone resistance under selection pressure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Drug Resistance, Bacterial / genetics*
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Escherichia coli K12 / drug effects
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Escherichia coli K12 / genetics*
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Escherichia coli K12 / growth & development
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Escherichia coli Proteins / genetics
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Evolution, Molecular*
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Fluoroquinolones / pharmacology*
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Humans
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Microbial Sensitivity Tests
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Mutation*
Substances
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Anti-Bacterial Agents
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Escherichia coli Proteins
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Fluoroquinolones