Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development

Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7942-8. doi: 10.1002/anie.200602785.
No abstract available

MeSH terms

  • 4-Butyrolactone / analogs & derivatives
  • 4-Butyrolactone / chemistry
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Cyclization
  • Epothilones / chemical synthesis*
  • Epothilones / pharmacology
  • HeLa Cells
  • Humans
  • Inhibitory Concentration 50
  • Models, Chemical
  • Time Factors
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents
  • Epothilones
  • pantolactone
  • ixabepilone
  • 4-Butyrolactone