Abstract
A molecular virology analysis performed in an HIV-hepatitis B virus (HBV) co-infected patient showed the emergence of an unusual HBV polymerase gene mutation (rt A181T) under adefovir therapy, conferring resistance to adefovir but not to tenofovir, as proved by in-vitro phenotypic analysis. This observation suggests that careful monitoring of co-infected patients is required to diagnose HBV resistance to nucleos(t)ide analogues, and that tenofovir may be active at least against some of the adefovir-resistant strains.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine / analogs & derivatives
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Adenine / therapeutic use
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Adult
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Drug Resistance, Viral
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Gene Products, pol / genetics*
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HIV Infections / complications*
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Hepatitis B virus / genetics*
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Hepatitis B, Chronic / complications
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Hepatitis B, Chronic / drug therapy*
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Humans
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Mutation / genetics*
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Organophosphonates / therapeutic use
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Reverse Transcriptase Inhibitors / therapeutic use*
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Tenofovir
Substances
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Gene Products, pol
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Organophosphonates
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P protein, Hepatitis B virus
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Reverse Transcriptase Inhibitors
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adefovir
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Tenofovir
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Adenine