Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease

Brain Res Bull. 2006 Dec 11;71(1-3):149-54. doi: 10.1016/j.brainresbull.2006.08.015. Epub 2006 Sep 20.

Abstract

This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1-1.5Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change=0.93+/-0.62; Wilcoxon: p=0.0002, n=13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain-electrode interface.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology
  • Adult
  • Aged
  • Artifacts
  • Basal Ganglia / anatomy & histology
  • Basal Ganglia / physiopathology
  • Biological Clocks / physiology*
  • Deep Brain Stimulation / methods*
  • Electrodes / standards
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nerve Net / anatomy & histology
  • Nerve Net / physiopathology
  • Neural Pathways / anatomy & histology
  • Neural Pathways / physiopathology
  • Parkinson Disease / physiopathology
  • Parkinson Disease / therapy*
  • Subthalamic Nucleus / anatomy & histology
  • Subthalamic Nucleus / physiology*
  • Treatment Outcome