Abstract
The present study deals with the effects of immunomodulators on the morphology of intracerebral arterial walls in rabbits with experimental subarachnoid haemorrhage (SAH). Immunostimulators:thymostimuline and inosine dimethylamino-isopropanol-p-acetamido-benzoate were found to aggravate the angiopathic changes, whereas immunosuppressive drugs-cyclosporine A and azathioprine appeared to prevent the damage. The authors consider the possibility of using immunosuppressive drugs in patients with ruptured intracranial aneurysms.
MeSH terms
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Animals
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Azathioprine / therapeutic use*
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Cerebral Arteries / drug effects*
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Cerebral Arteries / pathology
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Cyclosporins / therapeutic use*
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Endothelium, Vascular / drug effects
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Endothelium, Vascular / pathology
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Inosine Pranobex / therapeutic use
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Ischemic Attack, Transient / etiology
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Ischemic Attack, Transient / pathology
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Muscle, Smooth, Vascular / drug effects*
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Muscle, Smooth, Vascular / pathology
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Necrosis
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Rabbits
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Subarachnoid Hemorrhage / complications
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Subarachnoid Hemorrhage / drug therapy*
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Thymus Extracts / therapeutic use
Substances
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Cyclosporins
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Thymus Extracts
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thymostimulin
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Azathioprine
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Inosine Pranobex