To die or not to die: a HAT trick

Sandrine Tyteca; Gaëlle Legube; Didier Trouche

doi:10.1016/j.molcel.2006.12.005

To die or not to die: a HAT trick

Mol Cell. 2006 Dec 28;24(6):807-8. doi: 10.1016/j.molcel.2006.12.005.

Authors

Sandrine Tyteca¹, Gaëlle Legube, Didier Trouche

Affiliation

¹ LBME, CNRS and Université Paul Sabatier, 118 Route de Narbonne, 31062 Toulouse, France.

PMID: 17189182
DOI: 10.1016/j.molcel.2006.12.005

Abstract

In this issue of Molecular Cell, two manuscripts (Sykes et al., 2006) propose that the decision to undergo apoptosis upon DNA damage is mediated through acetylation of p53 within its DNA-binding domain by MYST histone acetyltransferases.

Publication types

Review
Kommentar

MeSH terms

Acetylation
Animals
Apoptosis
Apoptosis Regulatory Proteins / metabolism
Cell Cycle
Cyclin-Dependent Kinase Inhibitor p21 / metabolism
Histone Acetyltransferases / metabolism*
Histone Acetyltransferases / physiology*
Humans
Lysine Acetyltransferase 5
Proto-Oncogene Proteins / metabolism
Proto-Oncogene Proteins c-mdm2 / metabolism
Transcriptional Activation*
Tumor Suppressor Protein p53 / metabolism*
p300-CBP Transcription Factors / physiology

Substances

Apoptosis Regulatory Proteins
BBC3 protein, human
CDKN1A protein, human
Cyclin-Dependent Kinase Inhibitor p21
Proto-Oncogene Proteins
Tumor Suppressor Protein p53
Histone Acetyltransferases
KAT5 protein, human
KAT8 protein, human
Lysine Acetyltransferase 5
p300-CBP Transcription Factors
MDM2 protein, human
Proto-Oncogene Proteins c-mdm2