Oncogene-induced senescence pathways weave an intricate tapestry

Paul Yaswen; Judith Campisi

doi:10.1016/j.cell.2007.01.005

Oncogene-induced senescence pathways weave an intricate tapestry

Cell. 2007 Jan 26;128(2):233-4. doi: 10.1016/j.cell.2007.01.005.

Authors

Paul Yaswen¹, Judith Campisi

Affiliation

¹ Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., Berkeley, CA 94720, USA. [email protected]

PMID: 17254959
DOI: 10.1016/j.cell.2007.01.005

Abstract

The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53.

Publication types

Review
Kommentar

MeSH terms

Animals
Cell Proliferation
Cell Transformation, Neoplastic / genetics*
Cell Transformation, Neoplastic / metabolism
Cellular Senescence / genetics*
DNA Damage / genetics
Humans
Intracellular Signaling Peptides and Proteins
Mice
Oncogenes / genetics*
Phosphorylation
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism*
Signal Transduction / genetics
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / metabolism*

Substances

Intracellular Signaling Peptides and Proteins
Tumor Suppressor Protein p53
MAP-kinase-activated kinase 5
Protein Serine-Threonine Kinases