Recently, researchers have reported high musculoskeletal symptom prevalence at several US colleges. Since ergonomic interventions have been shown to prevent and reduce disability, it is important to identify the risk factors for developing symptoms among college students. A nested case-control study was completed to determine computer-related ergonomic risks associated with musculoskeletal symptoms. A trained observer completed ergonomic assessments on 52 randomly selected cases and controls. More than 75 percent (cases and controls combined) of the population was exposed to nine potential postural strains including: arms not along side during keying or mousing; lower back not supported; not having chair accessories; computer monitor not adjustable; mouse being too high or low; hand/wrist/forearm in contact with the desk edge; lack of wrist support; and keyboard not being adjustable. Cases and controls were equally likely to have substantially elevated risks but because the sample was small and lacked power, no risks were statistically significant. Since many known risk factors were prevalent in cases and controls, more research is required to evaluate and prevent injury in this population.