Synthesis of a fluorescence-labeled K30 antigen repeating unit using click chemistry

Carbohydr Res. 2007 May 21;342(7):975-81. doi: 10.1016/j.carres.2007.01.015. Epub 2007 Feb 1.

Abstract

An N-dansyl-labeled K30 antigen repeating unit, [4-[5-(N,N'-dimethylamino)naphthalene-1-sulfonamine]-1H-1,2,3-triazol-1-yl]hexyl beta-D-glucopyranosyluronate-(1-->3)-alpha-D-galactopyranosyl-alpha-D-mannopyranosyl-(1-->3)-beta-D-galactopyranoside, was synthesized using click chemistry, the copper(I)-catalyzed 1,3-dipolar cycloaddition reaction of an azide and an alkyne. The target compound could further facilitate the studies of interactions among K30 oligosaccharides and proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Bacterial / chemistry*
  • Antigens, Surface / chemistry*
  • Azides / chemistry
  • Carbohydrate Sequence
  • Catalysis
  • Copper / chemistry
  • Fluorescence*
  • Glycosylation
  • Oligosaccharides / chemical synthesis*
  • Oligosaccharides / metabolism

Substances

  • Antigens, Bacterial
  • Antigens, Surface
  • Azides
  • K antigens
  • Oligosaccharides
  • Copper