Abstract
embB306 mutants were detected in both ethambutol (EMB)-resistant and EMB-susceptible strains of Mycobacterium tuberculosis. Multidrug-resistant (MDR) strains had a higher proportion of embB306 mutants than non-MDR strains (odds ratio, 6.78; P < 0.001). The embB306 locus is a candidate marker for rapid detection of MDR and extremely drug resistant tuberculosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / pharmacology*
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Codon / genetics*
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial / genetics
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Ethambutol / pharmacology*
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Humans
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Mutation
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / isolation & purification
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Sensitivity and Specificity
Substances
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Antitubercular Agents
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Codon
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DNA, Bacterial
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Ethambutol