Abstract
Monoclonal gammopathy of uncertain significance (MGUS) may become symptomatic for autoimmune manifestations. We report on the prevalence and clinical course of immune thrombocytopenic purpura (ITP) observed in a consecutive series of 228 MGUS patients. At MGUS diagnosis, ITP was determined in 6/228 cases, accounting for a prevalence of 2630/100 000 [95% confidence interval (CI): 1210-5620]. One incidental ITP case occurred after 21 months of follow-up. After a follow-up of 681.3 patient-years, the crude incidence of ITP in MGUS was 146.8 per 100 000 patient-year (95% CI: 3.7-817.8). Overall, these observations point to an association between MGUS and ITP.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Anti-Inflammatory Agents / therapeutic use
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Cohort Studies
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Cyclophosphamide / therapeutic use
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Female
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Humans
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Immunosuppressive Agents / therapeutic use
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Male
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Monoclonal Gammopathy of Undetermined Significance / complications*
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Monoclonal Gammopathy of Undetermined Significance / metabolism
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Prednisone / therapeutic use
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Purpura, Thrombocytopenic, Idiopathic / complications*
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Purpura, Thrombocytopenic, Idiopathic / drug therapy
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Purpura, Thrombocytopenic, Idiopathic / metabolism
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Treatment Outcome
Substances
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Anti-Inflammatory Agents
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Immunosuppressive Agents
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Cyclophosphamide
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Prednisone