The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and its role in haematological malignancies

Domenico Ribatti; Angelo Vacca; Marco Rusnati; Marco Presta

doi:10.1016/j.cytogfr.2007.04.011

The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and its role in haematological malignancies

Cytokine Growth Factor Rev. 2007 Jun-Aug;18(3-4):327-34. doi: 10.1016/j.cytogfr.2007.04.011. Epub 2007 May 29.

Authors

Domenico Ribatti¹, Angelo Vacca, Marco Rusnati, Marco Presta

Affiliation

¹ Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy. [email protected]

PMID: 17537668
DOI: 10.1016/j.cytogfr.2007.04.011

Abstract

Basic fibroblast growth factor/fibroblast growth factor-2 is one of the best characterized of the pro-angiogenic cytokines. This review describes its history, as well as its role in tumor angiogenesis associated with haematological malignancies, as traced by the main contributions to the international medical literature.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Line, Tumor
Fibroblast Growth Factor 2 / metabolism*
Fibroblast Growth Factor 2 / physiology*
Gene Expression Regulation, Neoplastic*
Hematologic Neoplasms / metabolism*
Humans
Lymphoma / metabolism
Models, Biological
Neovascularization, Pathologic
Receptors, Fibroblast Growth Factor / metabolism

Substances

Receptors, Fibroblast Growth Factor
Fibroblast Growth Factor 2