Abstract
Interferon-gamma is a key cytokine in tumor immunosurveillance. The recently described interferon-producing killer dendritic cell (IKDC), can be distinguished from other innate effectors by its ability to kill a large variety of tumor cells and to produce high amounts of interferon-gamma after encountering tumors in the absence of exogenous cytokines. The cytotoxic activity of IKDC was unraveled during an efficient immunotherapy combining c-kit tyrosine kinase inhibitors and interleukin-2, and is mediated through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and interferon type IIR.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, Surface / metabolism
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Benzamides
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Dendritic Cells / cytology
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Dendritic Cells / metabolism*
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Humans
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Imatinib Mesylate
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Interferon-gamma / biosynthesis*
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Interferon-gamma / metabolism
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Interferon-gamma / physiology*
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Interleukin-2 / metabolism
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Killer Cells, Natural / metabolism*
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Lectins, C-Type / metabolism
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Leukocyte Common Antigens / metabolism
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Models, Biological
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NK Cell Lectin-Like Receptor Subfamily B
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Neoplasm Metastasis
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Neoplasms / metabolism
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Piperazines / pharmacology
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Proto-Oncogene Proteins c-kit / metabolism
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Pyrimidines / pharmacology
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TNF-Related Apoptosis-Inducing Ligand / metabolism
Substances
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Antigens, Surface
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Benzamides
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Interleukin-2
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KLRB1 protein, human
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Lectins, C-Type
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NK Cell Lectin-Like Receptor Subfamily B
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Piperazines
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Pyrimidines
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TNF-Related Apoptosis-Inducing Ligand
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Interferon-gamma
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Imatinib Mesylate
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Proto-Oncogene Proteins c-kit
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Leukocyte Common Antigens