Refractory psychotic symptoms in a patient with homozygous sickle cell disease: a 24-month follow-up

Pedro Gomes de Alvarenga; Marcus Vinicius Zanetti; Hélio Elkis

doi:10.1016/j.pnpbp.2007.07.015

Refractory psychotic symptoms in a patient with homozygous sickle cell disease: a 24-month follow-up

Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):301-3. doi: 10.1016/j.pnpbp.2007.07.015. Epub 2007 Jul 21.

Authors

Pedro Gomes de Alvarenga¹, Marcus Vinicius Zanetti, Hélio Elkis

Affiliation

¹ Department & Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil. [email protected]

PMID: 17720291
DOI: 10.1016/j.pnpbp.2007.07.015

Abstract

The present report describes a case of a 33-year old male patient with homozygous sickle cell disease (SCD) with comorbid psychotic symptoms. The systematical evaluation revealed an intimate association between acute SCD complications, associated with hematological abnormalities, and psychotic symptoms worsening. Clozapine was effective in controlling psychotic symptoms refractory to previous antipsychotic trials.

Publication types

Case Reports

MeSH terms

Adult
Anemia, Sickle Cell / complications*
Anemia, Sickle Cell / diagnostic imaging
Anemia, Sickle Cell / pathology
Antipsychotic Agents / therapeutic use
Black or African American
Clozapine / therapeutic use
Follow-Up Studies
Homozygote
Humans
Magnetic Resonance Imaging / methods
Male
Psychotic Disorders / complications*
Psychotic Disorders / diagnostic imaging
Psychotic Disorders / drug therapy
Psychotic Disorders / pathology
Tomography, Emission-Computed, Single-Photon

Substances

Antipsychotic Agents
Clozapine