Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide

Chem Commun (Camb). 2007 Jun 21:(23):2330-2. doi: 10.1039/b701177f.

Abstract

A novel [18F]NF reagent and two novel radiochemical transformations have been developed: [18F]NFSi has been prepared from sodium dibenzenesulfonimide and reacted in the presence of silyl enol ethers and allylsilanes to deliver labelled fluorinated ketones and allylic fluorides respectively; the radiosynthesis of the fluorinated A ring of vitamin D3 has also been completed with success.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Fluorine Radioisotopes / chemistry*
  • Radiometry
  • Sulfonamides / chemical synthesis*

Substances

  • Fluorine Radioisotopes
  • Sulfonamides
  • N-fluorobenzenesulfonimide