Abstract
A series of amino-caprolactam sulfonamides were developed from a screening hit. Compounds with good in vitro and in vivo gamma-secretase activity are reported.
MeSH terms
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Amyloid Precursor Protein Secretases / antagonists & inhibitors*
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Caprolactam / chemistry
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Caprolactam / pharmacology*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
Substances
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Enzyme Inhibitors
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Caprolactam
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Amyloid Precursor Protein Secretases