Shape memory behavior of novel (L-lactide-glycolide-trimethylene carbonate) terpolymers

Biomacromolecules. 2007 Nov;8(11):3661-7. doi: 10.1021/bm700773s. Epub 2007 Oct 17.

Abstract

Bioresorbable new terpolymers of L-lactide, glycolide, and trimethylene carbonate with different compositions were synthesized via ring-opening polymerization reaction of the cyclic monomers using low-toxicity zirconium(IV) acetylacetonate as initiator. The thermal and mechanical properties were investigated by means of thermogravimetry, differential scanning calorimetry, stress-strain measurements, and dynamical mechanical analysis. The glass transition temperature of the terpolymers changes with composition from 12 to 42 degrees C in a predictable manner. All terpolymers display shape memory properties and, after undergoing 100% deformation, they recover the permanent shape in a time frame of seconds. Terpolymers with high L-lactide content show a glass transition in the range of 38-42 degrees C, recovery temperature close to body temperature, and good recovery ratio (>0.89). Low-toxicity bioresorbable terpolymers with shape memory properties are promising new materials for biomedical applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calorimetry, Differential Scanning
  • Dioxanes / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Molecular Weight
  • Polyglactin 910 / chemical synthesis
  • Polyglactin 910 / chemistry*
  • Stress, Mechanical
  • Temperature
  • Tensile Strength

Substances

  • Dioxanes
  • Polyglactin 910
  • trimethylene carbonate