Abstract
One novel ansamycin, namely naphthomycin K, together with two known naphthomycins A and E, were isolated from the commensal strain Streptomyces sp. CS of the medicinal plant Maytenus hookeri. Their structures were elucidated by the analysis of NMR and MS data. Naphthomycin K showed evident cytotoxicity against P388 and A-549 cell lines, but no inhibitory activities against Staphylococcus aureus and Mycobacterium tuberculosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / isolation & purification
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Antibiotics, Antineoplastic / pharmacology
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Maytenus / chemistry
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Microbial Sensitivity Tests
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Molecular Conformation
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Mycobacterium tuberculosis / drug effects
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Naphthoquinones / isolation & purification
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Naphthoquinones / pharmacology*
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Rifabutin / chemistry
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Spectrometry, Mass, Electrospray Ionization
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Staphylococcus aureus / drug effects
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Streptomyces / chemistry*
Substances
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Antibiotics, Antineoplastic
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Naphthoquinones
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naphthomycin K
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Rifabutin