Abstract
Three new dimeric sesquiterpenoids, chloramultilides B-D ( 1- 3), along with 10 known sesquiterpenoids, were isolated from the whole plant of Chloranthus spicatus. Their structures were established by physical data (1D and 2D NMR, MS). The structure and absolute configuration of 1 was confirmed by X-ray crystallography. Compound 1 exhibited moderate in vitro antifungal activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Candida / drug effects*
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Leukemia P388
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Magnoliopsida / chemistry*
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Mice
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Molecular Conformation
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Molecular Structure
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Plants, Medicinal / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / classification
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
Substances
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Antifungal Agents
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Drugs, Chinese Herbal
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Sesquiterpenes
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chloramultilide B
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chloramultilide C
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chloramultilide D