Alkane hydroxylation by a nonheme iron catalyst that challenges the heme paradigm for oxygenase action

J Am Chem Soc. 2007 Dec 26;129(51):15766-7. doi: 10.1021/ja077761n. Epub 2007 Dec 5.

Abstract

A nonheme iron catalyst catalyzed stereoselective oxidation of alkanes with H2O2 with remarkable efficiency and exhibiting an unprecedented high incorporation of water into the oxidized products. The present results challenge the canonical description of oxygenases, the standard oxo-hydroxo tautomerism that applies to heme systems and serves as a precedent for alternative pathways for the oxidation of hydrocarbons at nonheme iron oxygenases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkanes / chemistry*
  • Catalysis
  • Heme / chemistry*
  • Hydroxylation
  • Iron / chemistry*
  • Oxidation-Reduction
  • Oxygenases / chemistry*
  • Stereoisomerism

Substances

  • Alkanes
  • Heme
  • Iron
  • Oxygenases