Abstract
Activity of simulated cefditoren urinary concentrations was determined against seven Escherichia coli isolates. Bactericidal activity was obtained from 4 to 24 h against TEM-1 (penicillinase production/hyperproduction), TEM-34 (IRT-6), and TEM-116 (extended-spectrum beta-lactamase [ESBL]) and from 6 to 8 h against SHV/TEM-116 (ESBL) but never against SHV/TEM-1 (ESBL). Extension of bactericidal activity depended on the resistance genotype/phenotype tested.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amdinocillin Pivoxil* / administration & dosage
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Amdinocillin Pivoxil* / pharmacokinetics
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Amdinocillin Pivoxil* / pharmacology
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Anti-Bacterial Agents* / administration & dosage
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Anti-Bacterial Agents* / pharmacokinetics
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Anti-Bacterial Agents* / pharmacology
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Anti-Infective Agents, Urinary* / administration & dosage
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Anti-Infective Agents, Urinary* / pharmacokinetics
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Anti-Infective Agents, Urinary* / pharmacology
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Cephalosporins* / administration & dosage
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Cephalosporins* / pharmacokinetics
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Cephalosporins* / pharmacology
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Escherichia coli / drug effects*
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Escherichia coli / enzymology
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Escherichia coli / genetics
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Escherichia coli / isolation & purification
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Escherichia coli Infections / microbiology
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Genotype
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Humans
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Microbial Sensitivity Tests
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Models, Biological
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Phenotype
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Urinary Tract Infections / microbiology
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Urine / chemistry*
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Urine / microbiology
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beta-Lactamases / biosynthesis
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents, Urinary
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Cephalosporins
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Amdinocillin Pivoxil
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cefditoren
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beta-Lactamases