Abstract
Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / immunology
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Adenocarcinoma / metabolism
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Adenocarcinoma / pathology
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Adult
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Aged
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Aged, 80 and over
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Antibodies, Neoplasm / biosynthesis
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Antibodies, Neoplasm / genetics
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Antibodies, Neoplasm / metabolism
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Antigens, Neoplasm / immunology*
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Antigens, Neoplasm / metabolism
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Cell Line, Tumor
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Colonic Neoplasms / immunology*
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Colonic Neoplasms / metabolism*
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Colonic Neoplasms / pathology
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Disease Progression
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Electrophoresis, Gel, Two-Dimensional
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Female
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HT29 Cells
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Humans
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Male
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Middle Aged
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Proteome / immunology*
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Proteome / metabolism
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Proteomics
Substances
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Antibodies, Neoplasm
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Antigens, Neoplasm
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Proteome