Abstract
To analyze the relationship between acute virus-induced injury and the subsequent disease phenotype, we compared the virus replication and CD4(+) T-cell profiles for monkeys infected with isogenic highly pathogenic (KS661) and moderately pathogenic (#64) simian-human immunodeficiency viruses (SHIVs). Intrarectal infusion of SHIV-KS661 resulted in rapid, systemic, and massive virus replication, while SHIV-#64 replicated more slowly and reached lower titers. Whereas KS661 systemically depleted CD4(+) T cells, #64 caused significant CD4(+) T-cell depletion only in the small intestine. We conclude that SHIV, regardless of pathogenicity, can cause injury to the small intestine and leads to CD4(+) T-cell depletion in infected animals during acute infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Viral / blood
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / virology*
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HIV Antibodies / blood
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HIV Infections / etiology
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HIV Infections / immunology
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HIV Infections / virology
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HIV-1 / pathogenicity*
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Humans
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Immunohistochemistry
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Intestinal Mucosa / cytology*
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Intestinal Mucosa / immunology
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Intestine, Small / cytology*
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Intestine, Small / immunology
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Macaca mulatta
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Proviruses / isolation & purification
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RNA, Viral / blood
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Random Allocation
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Simian Acquired Immunodeficiency Syndrome / etiology
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Simian Acquired Immunodeficiency Syndrome / immunology
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Simian Acquired Immunodeficiency Syndrome / virology
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Simian Immunodeficiency Virus / pathogenicity*
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Viral Load
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Virus Replication
Substances
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Antibodies, Viral
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HIV Antibodies
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RNA, Viral