Pretreatment with gonadotropin-releasing hormone (GnRH) antagonists to prevent the flare-up effect of long-acting GnRH agonists: results of a pilot study

Andreas Mueller; Theodoros Maltaris; Lothar Häberle; Inge Hoffmann; Matthias W Beckmann; Ralf Dittrich

doi:10.1016/j.fertnstert.2007.11.066

Pretreatment with gonadotropin-releasing hormone (GnRH) antagonists to prevent the flare-up effect of long-acting GnRH agonists: results of a pilot study

Fertil Steril. 2009 Feb;91(2):647-8. doi: 10.1016/j.fertnstert.2007.11.066. Epub 2008 Apr 18.

Authors

Andreas Mueller¹, Theodoros Maltaris, Lothar Häberle, Inge Hoffmann, Matthias W Beckmann, Ralf Dittrich

Affiliation

¹ Department of Obstetrics and Gynecology, Erlangen University Hospital, Erlangen, Germany. [email protected]

PMID: 18423456
DOI: 10.1016/j.fertnstert.2007.11.066

Abstract

This study evaluated in vivo whether the flare-up effect of GnRH agonists can be suppressed through pretreatment with a GnRH antagonist. The classic flare-up effect caused by 3.8 mg goserelin acetate could not be suppressed through pretreatment using a single dosage of 3.24 mg cetrorelix acetate.

Publication types

Clinical Trial

MeSH terms

Estradiol / blood
Female
Follicle Stimulating Hormone, Human / blood
Gonadotropin-Releasing Hormone / agonists
Gonadotropin-Releasing Hormone / analogs & derivatives*
Gonadotropin-Releasing Hormone / antagonists & inhibitors
Gonadotropin-Releasing Hormone / therapeutic use
Goserelin / therapeutic use*
Hormone Antagonists / therapeutic use*
Humans
Luteinizing Hormone / blood
Male
Pilot Projects
Testosterone / blood
Time Factors
Transsexualism / blood
Transsexualism / drug therapy*
Treatment Outcome

Substances

Follicle Stimulating Hormone, Human
Hormone Antagonists
Goserelin
Gonadotropin-Releasing Hormone
Testosterone
Estradiol
Luteinizing Hormone
cetrorelix