Rhodium(I)-catalyzed cycloisomerizations of bicyclobutanes

J Am Chem Soc. 2008 Jun 4;130(22):6924-5. doi: 10.1021/ja802906k. Epub 2008 May 8.

Abstract

The selection of rhodium precatalyst and phosphine ligand determines the course of the cycloisomerization of N-allylated bicyclo[1.1.0]butylalkylamines. Cyclopropane-fused pyrrolidines and azepines are obtained with high levels of stereo- and regiocontrol. Novel azatricyclo[6.1.0.0(1,5)]nonanes are the result of a tandem cycloisomerization-ring closing metathesis sequence. Allylic ethers lead to furans and oxepanes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Azepines / chemical synthesis*
  • Bridged Bicyclo Compounds / chemistry*
  • Catalysis
  • Cyclization
  • Cyclobutanes / chemistry*
  • Isomerism
  • Phosphines / chemistry
  • Pyrrolidines / chemical synthesis*
  • Rhodium / chemistry*

Substances

  • Azepines
  • Bridged Bicyclo Compounds
  • Cyclobutanes
  • Phosphines
  • Pyrrolidines
  • Rhodium