Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

Science. 2008 May 23;320(5879):1012; author reply 1012. doi: 10.1126/science.1152366.

Abstract

Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.

Publication types

  • Kommentar

MeSH terms

  • Animals
  • Brain / metabolism*
  • Crosses, Genetic
  • Diet
  • Female
  • Homeostasis
  • Insulin Receptor Substrate Proteins
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Kaplan-Meier Estimate
  • Longevity*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mutation
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism*
  • Research Design
  • Signal Transduction

Substances

  • Insulin Receptor Substrate Proteins
  • Intracellular Signaling Peptides and Proteins
  • Irs2 protein, mouse
  • Phosphoproteins