Abstract
The retrospective study of 34 patients with Hodgkin lymphoma-associated hemophagocytic syndrome led us to define this association as a specific disorder. Its characteristics are male predominance (male-to-female sex ratio, 3.3:1), immunodeficiency-like histological features (lymphocyte depletion, 45% of cases; mixed cellularity Hodgkin lymphoma subtype, 40%), and strong association with Epstein-Barr virus (94%).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Epstein-Barr Virus Infections / complications*
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Epstein-Barr Virus Infections / virology
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Female
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Herpesvirus 4, Human / isolation & purification*
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Hodgkin Disease / complications*
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Hodgkin Disease / virology*
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Humans
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Lymphohistiocytosis, Hemophagocytic / epidemiology
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Lymphohistiocytosis, Hemophagocytic / etiology*
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Lymphohistiocytosis, Hemophagocytic / pathology
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Lymphohistiocytosis, Hemophagocytic / virology*
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Male
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Middle Aged