Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist

Neuron. 2008 Jul 10;59(1):8-10. doi: 10.1016/j.neuron.2008.06.014.

Abstract

In this month's issue of Nature Medicine, Town et al. suggest that peripheral macrophages invading the brain reduce cerebral amyloidosis and thus may play a key role in the pathogenesis of Alzheimer's disease (AD). This observation intensifies the longstanding controversy of whether mononuclear cells such as macrophages and/or microglial cells are beneficial or detrimental in AD.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease* / metabolism
  • Alzheimer Disease* / pathology
  • Alzheimer Disease* / therapy
  • Amyloid / metabolism*
  • Animals
  • Cerebral Cortex / metabolism
  • Cerebral Cortex / pathology
  • Humans
  • Peripheral Nerves / metabolism
  • Peripheral Nerves / pathology
  • Phagocytes / physiology*

Substances

  • Amyloid