Effect of clomiphene citrate upon periovulatory endometrial development in the baboon

J Med Primatol. 1991;20(2):49-57.

Abstract

Endometrial histology in baboons (Papio cynocephalus anubis) was evaluated after five days of clomiphene citrate (CC) treatment initiated on either cycle day six (n = 8) or ten (n = 4). Biopsies performed before and after a human chorionic gonadotropin (hCG) induced ovulation were compared to non-CC treated controls. Although CC had a definite antiestrogenic effect on perineal skin, no significant effect of endometrial proliferation was demonstrable.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biopsy, Needle / veterinary
  • Clomiphene / pharmacology*
  • Endometrium / drug effects*
  • Endometrium / growth & development
  • Endometrium / ultrastructure
  • Female
  • Luteal Phase
  • Menstrual Cycle
  • Microscopy, Electron, Scanning
  • Ovulation*
  • Papio / physiology*
  • Perineum
  • Skin / drug effects

Substances

  • Clomiphene