The deep location and eloquent surroundings of the ventricular system within the brain have historically posed significant and often formidable challenges for the optimal resection of tumors in these locations. The evolution and advances in microsurgical techniques and neuroanatomic knowledge have led to a general paradigm shift from transcerebral trajectories to transcisternal corridor strategies. The essence of microsurgery of the ventricular system has evolved around the concept of circumnavigating eloquent cortical and white matter structures to achieve minimally invasive access and resection while optimizing functional and cognitive outcomes.