Abstract
This paper describes a series of modifications of the side chain of micromolide, an anti-tuberculosis natural product. Most of the synthesized compounds showed significantly decreased activities, which suggests that the long aliphatic side chain of micromolide and its double bond are essential to its activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemical synthesis*
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Alkenes / chemistry
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Alkenes / pharmacology*
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Antitubercular Agents / chemical synthesis*
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Antitubercular Agents / chemistry
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Antitubercular Agents / pharmacology*
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Biological Products / chemistry*
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Combinatorial Chemistry Techniques
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Lactones / chemical synthesis*
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Lactones / chemistry
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Lactones / pharmacology*
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Molecular Structure
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Plants, Medicinal / chemistry
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Structure-Activity Relationship
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Tuberculosis / drug therapy*
Substances
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Alkenes
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Antitubercular Agents
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Biological Products
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Lactones
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micromolide