Abstract
Quinoid inhibitors of Cdc25B were designed based on the Linear Combination of Atomic Potentials (LCAP) methodology. In contrast to a published hypothesis, the biological activities and hydrogen peroxide generation in reducing media of three synthetic models did not correlate with the quinone half-wave potential, E(1/2).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Cell Line, Tumor
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Cell Survival / drug effects
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Combinatorial Chemistry Techniques
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Computer Simulation
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Drug Design*
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Drug Evaluation, Preclinical
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Humans
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Hydrogen Peroxide
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Molecular Structure
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Oxidation-Reduction / drug effects
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Quinones / chemical synthesis*
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Quinones / chemistry
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Quinones / pharmacology*
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Structure-Activity Relationship
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Substrate Specificity
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cdc25 Phosphatases / antagonists & inhibitors*
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cdc25 Phosphatases / metabolism
Substances
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Enzyme Inhibitors
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Quinones
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Hydrogen Peroxide
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cdc25 Phosphatases