Abstract
We demonstrate that xylitol can be added to polymethylmethacrylate (PMMA) bone cement to enhance the elution of daptomycin in terms of both the peak and sustained release of antibiotic. We also demonstrate that a PMMA-xylitol formulation optimized for daptomycin can be used to enhance the elution of both vancomycin and gentamicin.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Bone Cements / chemistry
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Chemistry, Pharmaceutical
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Daptomycin / administration & dosage*
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Daptomycin / pharmacokinetics*
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Drug Carriers / chemistry
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Gentamicins / administration & dosage
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Gentamicins / pharmacokinetics
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Polymethyl Methacrylate / chemistry*
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Vancomycin / administration & dosage
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Vancomycin / pharmacokinetics
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Xylitol / chemistry*
Substances
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Bone Cements
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Drug Carriers
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Gentamicins
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Vancomycin
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Polymethyl Methacrylate
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Daptomycin
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Xylitol