Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline

Chembiochem. 2009 Jan 26;10(2):246-50. doi: 10.1002/cbic.200800652.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Escherichia coli / genetics
  • Ligases / chemistry
  • Ligases / metabolism*
  • Molecular Sequence Data
  • Proline / analogs & derivatives*
  • Proline / biosynthesis*
  • Stereoisomerism
  • Streptomyces / enzymology*
  • Thienamycins / biosynthesis*
  • Thienamycins / chemistry*

Substances

  • (2S,5S)-trans-carboxymethylproline
  • Thienamycins
  • Proline
  • Ligases
  • thienamycin